In Romans Chapter one we see the fate of those who reject the evidence all around them of God's character. They see and know, in their heart of hearts, but reject God and His righteousness. Because they reject Him and want nothing to do with Him God removes Himself from them. When God leaves us alone we are left to our own devices. Without the prompting of the Holy Spirit they were given up to uncleanness or sinful desires (Romans 1: 24), vile passions or shameful desires
